I'm always a little hesitant to give away some lesser-known hiking spots because I enjoy a nice secluded hike. However I want people to experience all nature has to offer. So here's a moderate hike that's fairly accessible.
Eastatoe Creek Heritage Preserve Trail
The Eastatoe Creek Heritage Preserve Trail is a spur off the Foothills Trail near Sunset, South Carolina. Head north on US 178 from Pickens. A couple miles before you hit the North Carolina border, hang a left on Laurel Valley Road then an immediate right on Horse Pasture Road, which will be graveled. About a mile down this gravel road there will be a parking area on your left. There are several trails heads in this area. To access the Eastatoe trail, walk down the gravel road heading north from the parking are. After about a half-mile there will be a red gate on your left where the Foothills Trail spur will start. Follow the signs for Eastatoe trail and look for a white blaze.
The trail is moderate in difficulty but the way back will be a little more challenging so be prepared. The almost 2-mile trail ends at the Eastatoe Creek. Follow the signs to the Narrows for a great view of the falls. For the more adventurous, keep following the trail down to the creek. It's a steep climb down but the trail is well marked.